Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci
نویسندگان
چکیده
منابع مشابه
Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci.
LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genomes. Due to their high levels of sequence identity and the existence of many polymorphic insertions absent from the reference genome, the transcriptional activation of individual ...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.13926